This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.


Prediction tool for the worsening of urinary symptoms in prostate cancer patients treated with external beam radiotherapy

This tool predicts the probability that a patient will experience a severe worsening of urinary symptoms at the end of radiotherapy as described by the International Prostate Symptom Score (IPSS) [1]

To which patients does this tool apply?

The tool applies to patients with a hystologically confirmed diagnosis of localized prostate cancer (in low, intermediate or high risk class following NCCN guidelines), not previously subjected to prostatectomy, without severe urinary impairment at baseline (IPSS<20), treated with external beam radiotherapy with radical intent with conventional or moderately hypofractionated regimens (2-2.7 Gy/fr).

The model was validated on an external population of patients with a hystologically confirmed diagnosis of localized prostate cancer (intermediate or high risk class following NCCN guidelines), not previously subjected to prostatectomy, without severe urinary impairment at baseline (IPSS<20), treated with external beam radiotherapy with radical intent with conventional fractionation (2-Gy/fr) [2].

How was this tool developed?

The prediction model is based on data of 380 prostate cancer patients, treated at 9 Italian Institutes with external beam radiotherapy with conventional or moderately hypofractionated regimens and built using a numerical methodology that combines advanced techniques of data mining. The predicted outcome is the severe worsening of urinary symptoms at the end of therapy. Two endpoints were considered: 1) increase of at least 10 points in IPSS score (deltaIPSS >= 10); 2) increase of at least 15 points (deltaIPSS>=15)

Patients with missing values in IPSS values or dosimetric variables were not included. All other missing values were imputed using the most frequent values, for categorical parameters and the average for continuous parameters.

The choice of leading variables was performed through backward feature selections based on minimization of residuals performed on 1000 bootstrap resamplings of the original dataset, plus a basket and network analysis of the bootstrapped datasets. The variables were ranked according to their position in each backward selection by using a normalized index called NArea. Two sets of 8 and 4 variables were chosen for model 1) and 2), respectively. The Odds Ratios of the selected variables were calculated with logistic regressions on 1000 bootstrap resampling, their median values and 5th and 95th percentiles were evaluated.

Performance of the model in the development dataset was evaluated with the Area Under the ROC Curve (AUC), calibration and likelihood [1]. The performance of the model was validated in [2] with Brier score, AUC and calibration.

What information do you need?

  • Model 1 (ΔIPSS≥10):
    • Neoadjuvant hormone therapy (yes/no)
    • Planning Target Volume (in units of 10 cm3)
    • Absolute volume receiving at least 8.5 Gy per week (cm3)
    • Age (years)
    • Hypertension (yes/no)
    • Use of cardiovascular drugs (yes/no)
    • Body mass index (kg/m2)
    • Use of 5-alpha-reductase inhibitors (yes/no)
  • Model 2 (ΔIPSS≥15):
    • Use of anti-hypercolesterolemia drugs (yes/no)
    • Use of cardiovascular drugs (yes/no)
    • Neoadjuvant hormone therapy (yes/no)
    • Absolute volume receiving at least 12 Gy per week (cm3)

Journal articles that support this prediction tool

Palorini F, Rancati T, Cozzarini C, Improta I, Carillo V, Avuzzi B, Casanova Borca V, Botti A, Degli Esposti C, Franco P, Garibaldi E, Girelli G, Iotti C, Maggio A, Palombarini M, Pierelli A, Pignoli E, Vavassori V, Valdagni R, Fiorino C "Multi-variable models of large International Prostate Symptom Score worsening at the end of therapy in prostate cancer radiotherapy". Radiother Oncol. 2016 Jan;118(1):92-8. doi: 10.1016/j.radonc.2015.11.036 [PubMed] [ScienceDirect]

Yahya N, Ebert MA, Bulsara M, Kennedy A, Joseph DJ, Denham JW "Independent external validation of predictive models for urinary dysfunction following external beam radiotherapy of the prostate: Issues in model development and reporting". Radiother Oncol. 2016 Jun 28. pii: S0167-8140(16)31113-6. doi: 10.1016/j.radonc.2016.05.010 [PubMed] [ScienceDirect]

Aknowledgements

Aknowledgements to Associazione Italiana per la Ricerca sul Cancro (grants IG14603, IG13090, IG16087) and to Fondazione Italo Monzino