This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.


Prediction tool for pathologic complete response of locally advanced rectal cancer patients

This tool predicts the probability that a patient with locally advanced rectal cancer (LARC) will have a pathologic complete response after long course chemoradiotherapy (CRT) and surgery.

Required characteristics to use the tool

  • Locally advanced rectal cancer
  • Long course radiotherapy with doses between 48-55 Gy
  • Administration of at least one type of chemotherapy
  • Tumor size assessed by MR-imaging, and if not available, by CT-imaging or endoscopy
  • One PET scan before chemoradiotherapy and one PET scan two months after the end of radiochemotherapy
  • Absence of a distant metastasis at the time of the posttreatment PET scan

Required inputs

  • Tumor length assessed with MRI (or endoscopy)
  • SUVmax in tumour in pretreatment PET scan
  • SUVmax in tumour in posttreatment PET scan (2 months after end of treatment)

Development

The prediction model is based on data of 107 LARC patients, treated at Rovigo (Italy) with 50-55 Gy radiotherapy and chemotherapy with 5-fluorouracil (5-FU, 300 mg/m2/day), concomitantly with radiation. The tool was validated on a pooled dataset of 55 patients treated with equivalent treatment in Maastricht (The Netherlands), Rome (Italy) and Leuven (Belgium).

The available clinical variables were age, gender, clinical tumour and nodal stage, tumour location (1: low, 0-5 cm from anal verge; 2:mid, 5-10 cm from anal verge; 3: high, >10 cm from anal verge) and tumour length (cm). From the semi-automatic contoured PET scans For the patients who had PET-CT scans, maximal tumour diameter, gross tumour volume, and maximal and mean SUV values within the GTV were calculated. For the post-CRT PET-CT scan the response index (RI) for each SUV variable was calculated. For variable X, the response index is the relative percent difference between the value of the post-CRT and pre-CRT and it was defined as RI = (Xpre - Xpost)/Xpre * 100%. Pathological complete response was defined as ypT0N0, extracted from the pathologic reports of surgical specimens.

Any missing values in the data were imputed by the mean or most common value. The model performance was evaluated by analysing the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. The maximum value of the AUC is 1.0, indicating a perfect prediction model; a value of 0.5 indicates a random chance of correct prediction. Predictors were selected by exhaustive feature selection and evaluation of the 5% best AUC predictor sets. The models were trained to classify complete responders by using a proximal support vector machine. Logistic regression was used to convert model output to a probability for outcome.

We have developed also prediction models based on only clinical variables and based on pretreatment PET. However, the performances of these models are however not high enough (Figure 1). The best model including the pre- and post treatment PET scans resulted in an AUC of 0.83 for training and 0.86 for validation.

Performance best model;
Figure 1. A. AUCs for training and validation datasets for the three models: only clinical data, pretreatment PET data and pre+post PET data. B. ROC curves for the pre+post treatment model

Journal articles that support this prediction tool

van Stiphout RG, Lammering G, Buijsen J, Janssen MH, Gambacorta MA, Slagmolen P, Lambrecht M, Rubello D, Gava M, Giordano A, Postma EO, Haustermans K, Capirci C, Valentini V, Lambin P, Development and external validation of a predictive model for pathological complete response of rectal cancer patients including sequential PET-CT imaging, Radiotherapy and Oncology, 2010 [Epub ahead of print] [PubMed] [Journal]