This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.


Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging

This tool predicts the probability that a laryngeal carcinoma patient will be alive.

Required characteristics to use the tool

This tool was developed for laryngeal carcinoma patients, stage I-IV. Patients have to be treated with high dose radiotherapy alone. They have not undergone surgical treatment or chemotherapy, nor have distant metastasis at the time of diagnosis.

Development

Purpose: Due to the established role of the human papillomavirus (HPV), the optimal treatment for oropharyngeal carcinoma is currently under debate. We evaluated the most important determinants of treatment outcome to develop a multifactorial predictive model that could provide individualized predictions of treatment outcome in oropharyngeal carcinoma patients.

Methods: We analyzed the association between clinico-pathological factors and overall and progression-free survival in 168 OPSCC patients treated with curative radiotherapy or concurrent chemo-radiation. A multivariate model was validated in an external dataset of 189 patients and compared to the TNM staging system.

Results: Predictors of unfavorable outcomes were negative HPV-status, moderate to severe comorbidity, T3-T4 classification, N2b - N3 stage, male gender, lower hemoglobin levels and smoking history of more than 30 pack years. Prediction of overall survival using the multi-parameter model yielded a C-index of 0.82 (95% CI, 0.76 - 0.88). Validation in an independent dataset yielded a C-index of 0.73 (95% CI, 0.66 - 0.79. For progression-free survival, the model's C-index was 0.80 (95% CI, 0.76 - 0.88), with a validation C-index of 0.67, (95% CI, 0.59 - 0.74). Stratification of model estimated probabilities showed statistically different prognosis groups in both datasets (p < 0.001).

Conclusion: This nomogram was superior to TNM classification or HPV status alone in an independent validation dataset for prediction of overall and progression-free survival in OPSCC patients, assigning patients to distinct prognosis groups. These individualized predictions could be used to stratify patients for treatment de-escalation trials.

Nomogram
OSCC_Nomogram
The figure shows multivariate model converted to a graphic nomogram for prediction of progression free overall survival. Each variable in the model, corresponding to the characteristics of an individual patient, is assigned to an individual score. A probability for overall progression free survival can be calculated by drawing a vertical line from each predictor value to the score scale at the top—'points'. After manually summing up the scores, the 'total points' correspond to the probability of overall progression free survival (or progression free survival respectively), which are estimated by drawing a vertical line from this value to the bottom scales to estimate overall survival. Smoking was categorized as none, moderate (1–30 pack years of smoking) and heavy (>30 pack years of smoking).

Required information:

  • Hemoglobin level
  • Gender
  • Smoking
  • T-stage (Clinical T stage (I - IV))
  • Nodal involment (Clinical N stage)
  • HPV
  • Comorbidity

Journal articles that support this prediction tool

Emmanuel Rios Velazquez, Frank Hoebers, Hugo J.W.L. Aerts, Michelle M. Rietbergen, Ruud H. Brakenhoff, C. René Leemans, Ernst-Jan Speel, Jos Straetmans, Bernd Kremer, Philippe Lambin. Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging., DOI: 10.1016/j.radonc.2014.09.005 [CancerData] [Journal]

Emmanuel Rios Velazquez; Erratum: "Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging." [PubMed]