This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.

This website is designed to inform physicians and provide them with probability scores for a number of outcomes. The models calculate the probability that certain side-effects, treatment outcomes and follow-up outcomes will occur. ptTheragnostic B.V. does not record prediction tool user outcome.

These models should only be used by physicians who are familiar with the complexity of treatment decisions in cancer treatment and should not be used directly by patients. We emphasize that the purpose of these models is to inform physicians and that the models should not be used for decision support. The models available on this website are not regarded as medical devices under the current MEDDEV guidelines from the European Commission.

The calculators which are provided are freeware for personal use only. They are not public domain software and may not be sold or used for commercial purposes. Permission to use and backup this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted. Permission to distribute this software for any non-commercial purpose, without fee, and without a written agreement is hereby granted, provided that a reference to the following website and the entire License and Disclaimer are provided with all distributed copies: http://www.PredictCancer.org

The authors have made every effort to ensure that the information provided by this software is accurate and conforms to the methods described in the publications. However, the probability estimates published in the papers and which are estimated with these calculators may differ from those found in current clinical practice. In addition, a patient's prognosis may depend on other factors than those taken into account here. Thus, any decisions concerning patient care should not be based only on the use of these calculators, but should also take into account the patient's past history and other current patient and tumor characteristics. The model output supplements but does not substitute this individual clinical assessment. The creators of the PredictCancer website are not liable for clinical decision making that occurs between a physician and a patient.

As medical science is constantly changing and human error is always possible, the information contained in the prediction tools may be outdated, incomplete or incorrect. The authors, ptTheragnostic and MAASTRO clinic do not warrant the calculators' accuracy nor are they responsible for any omissions, errors or outcomes resulting from the use of these calculators. In no event shall either the authors, ptTheragnostic or MAASTRO clinic be liable to any party for any direct, indirect, special, incidental, or consequential damages, including lost profits, arising from the use of this software even if they have been advised of the possibility of such damage.

The authors, ptTheragnostic and MAASTRO clinic specifically disclaim any warranties, including but not limited to, the implied warranty of fitness for calculating the probabilities of outcomes for patients. The software provided hereunder is on an as is basis and neither the authors, ptTheragnostic nor the MAASTRO clinic have any obligations to provide maintenance, support, updates, enhancements or modifications.

By proceeding with use of the models, the user agrees that they have read and agreed with these terms.


Decision analytic model for exploring the cost-effectiveness of intensity-modulated radiotherapy with photons as opposed to intensity-modulated proton radiotherapy in head and neck cancer.

Description

This tool was developed for patients with locally advanced head and neck cancer (oral cavity, laryngeal and pharyngeal cancer), who are eligible for potentially curative loco-regional treatment and have not been treated for another malignancy. At the time of diagnosis, patient should not have RTOG grade 2 or higher dysphagia or xerostomia, nor distant metastasis.

The decision analytic model calculates the estimated costs and quality-adjusted life years (QALYs) after intensity-modulated proton radiotherapy (IMPT) and intensity-modulated radiotherapy with photons (IMRT). As described in the accompanying published article (Ramaekers BL et al. Int J Radiat Oncol Biol Phys; In press), treating all HNC patients with IMPT is not a cost-effective strategy. However, administering IMPT only to a selected group of patients could be a cost-effective treatment strategy. This decision analytic model can be used to obtain patient specific outcomes and support clinical decision-making.

Please read the disclaimer before using the outcomes of the decision analytic model.

Development of the tool

The decision analytic (Markov) model consisted of 7 health states (as illustrated in Figure 1):

  1. disease free without toxicity
  2. disease free with xerostomia RTOG grade ≥2
  3. disease free with xerostomia and dysphagia RTOG grade ≥2
  4. disease free with dysphagia RTOG grade ≥2
  5. locoregional recurrence
  6. distant metastasis
  7. death

To incorporate the reversibility of acute toxicity during the first 6 months after radiation therapy, a cycle time of 6 months was used in the first year; afterward the cycle time was 1 year. A lifetime time horizon was used.

Markov
Figure 1: Diagrammatical representation of the model structure

The estimated differences between IMPT and IMRT are largely based on dose-response models to predict xerostomia and dysphagia at 6 (N = 354 and 354 respectively) and 12 months (N = 251 and 230 respectively) after radiotherapy. For the development of these dose-response models, a multivariate logistic regression analysis was used with an extended bootstrapping technique and forward variable selection (described by El Naqa et al. Int. J. Radiat. Oncol. Biol.Phys. 2006;64:127586). Model performance (internal validation) was determined by calculating the area under the curve (AUC) of the receiver operating characteristic The AUC of these dose-response models ranged between 0.776 and 0.809. An AUC of 0.80 indicates a 80% probability that a patient with the toxicity had a higher predicted probability than a patient without toxicity, for a random pair of patients with and without toxicity. No external validation was performed.

The abovementioned dose-response models were combined with individual data on the expected dose to ipsilateral parotis, the contralateral parotis, the pharyngeal constrictor muscle superior and the supraglottic area to calculated the probability of xerostomia and dysphagia (6 and 12 months after radiotherapy). The dose parameters for IMPT and IMRT were retrieved from a comparative planning study based on 25 patients (Van der Laan HP et al. Acta Oncol. 2013;52(3):561-9).

Costs and quality of life data used in the tool were retrieved from a cross-sectional study of 396 patients treated at MAASTRO CLINIC or at the University Medical Center Groningen (see Ramaekers BL et al. Oral Oncol. 2011;47(8):768-74).

The health care perspective was used to calculate costs (2010 price level). Unit prices and resource use were based on guidelines, a cross-sectional survey or if necessary expert opinion.

Required information to use the decision analytic model

The treatment dependent parameters listed in Table 1 have to be filled out with patient specific parameters in order to derive the estimated outcomes.

Table 1: Input parameters
Treatment independent parameters
Willing to pay () per QALY gained
Treatment dependent parameters*
Mean dose to ipsilateral parotis
Mean dose to contralateral parotis
Mean dose to pharyngeal constrictor muscle superior
Mean dose to supraglottic area
*Estimates for both IMPT and IMRT are required.


Journal articles that support this decision analytic model

Ramaekers BL, Grutters JP, Pijls-Johannesma M, Lambin P, Joore MA, Langendijk JA. Protons in head and neck cancer: bridging the gap of evidence. Int J Radiat Oncol Biol Phys; In press 2012. [Pubmed] [PDF] [Journal]

Ramaekers BL, Joore MA, Grutters JP, van den Ende P, Jong Jd, Houben R, Lambin P, Christianen M, Beetz I, Pijls-Johannesma M, Langendijk JA. The impact of late treatment-toxicity on generic health-related quality of life in head and neck cancer patients after radiotherapy. Oral Oncol. 2011 Aug;47(8):768-74. [Pubmed] [PDF] [Journal]

Ramaekers BL, Pijls-Johannesma M, Joore MA, van den Ende P, Langendijk JA, Lambin P, Kessels AG, Grutters JP. Systematic review and meta-analysis of radiotherapy in various head and neck cancers: comparing photons, carbon-ions and protons. Cancer Treat Rev. 2011 May;37(3):185-201. [Pubmed] [PDF] [Journal]

Christianen ME, Schilstra C, Beetz I, Muijs CT, Chouvalova O, Burlage FR, Doornaert P, Koken PW, Leemans CR, Rinkel RN, de Bruijn MJ, de Bock GH, Roodenburg JL, van der Laan BF, Slotman BJ, Verdonck-de Leeuw IM, Bijl HP, Langendijk JA. Predictive modelling for swallowing dysfunction after primary (chemo)radiation: results of a prospective observational study. Radiother Oncol. 2012 Oct;105(1):107-14. [Pubmed] [Journal]

Van der Laan HP, van de Water TA, van Herpt HE, Christianen ME, Bijl HP, Korevaar EW, Rasch CR, van 't Veld AA, van der Schaaf A, Schilstra C, Langendijk JA; ROCOCO cooperative group. The potential of intensity-modulated proton radiotherapy to reduce swallowing dysfunction in the treatment of head and neck cancer: A planning comparative study. Acta Oncol. 2013;52(3):561-9. [Pubmed] [Journal]